- Tumor Antigen Reactivity Plays Important Role in TIL Therapy Efficacy
- First-time Production of an Artificial Human Platelet Lysate
- Andelyn’s Platform Used to Manufacture Clinical Grade Viral Vector
- AI Designed DNA Sequences Modulate Cell Differentiation for Gene Therapy Applications
- In Vivo Bioprinting Shows Promise for 3D Printed Implants Without Surgery
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Machine Learning Engineers Bespoke Cas9 Enzymes for Gene Editing
In a new study published in Nature titled, “Custom CRISPR-Cas9 PAM variants via scalable engineering and machine learning,” researchers from Massachusetts General Hospital (MGH) and Harvard Medical School (HMS) have developed a machine learning model that permits the prediction of bespoke Cas9... -
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Region Specific Shifts in Dopamine Signaling Plays Role in Learning to Avoid Danger
Dopamine is the brain’s motivational spark, driving us to chase what feels good and steer clear of what doesn’t. But scientists haven’t fully understood how dopamine helps us learn to avoid bad outcomes. A study in mice carried out by researchers at Northwestern University has now found that... -
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EditCo, Promega to Combine CRISPR Knock-In Capabilities with Protein-Labeling Tech
EditCo Bio and Promega have announced a strategic licensing agreement that grants EditCo access to Promega’s HiBiT, HaloTag, and NanoLuc technologies. Under the terms of the arrangement, EditCo will incorporate Promega’s bioluminescent and protein-labeling technologies into its CRISPR-engineered... -
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This Week in Gaming News: April 14th – April 20th, 2025
Spring continues, and so does the gaming industry, so as usual, there’s plenty to discuss and pore over this week when it comes to gaming news. Whether it’s new Star Wars game announcements, more information about the Oblivion remake that everyone has admitted exists except for Bethesda, or new... -
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Pangenome Reference Incorporates 145 Wild and Cultivated Rice Genomes
A rice pangenome map that incorporates the genomes of nearly 150 wild and cultivated rice varieties has been constructed, capturing much of the genetic diversity found in this plant, including genes associated with disease resistance. This work, published in Nature in the paper, “A pangenome... -
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Structure of Mitochondrial Pyruvate Carrier Drug Target Bound to Inhibitors Revealed
Scientists led by a team at the Medical Research Council (MRC) Mitochondrial Biology Unit, University of Cambridge, have worked out how a molecular machine found in mitochondria—the “powerhouses” of our cells—allows us to make the fuel we need from sugars, a process vital to all life on Earth... -
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How Did Scientists Become the Enemy?
Hana El-Samad, PhD On July 20, 1969, Apollo 11 landed on the moon, a defining moment in American history. An estimated 650 million people globally watched the lunar landing live, including those in the 94% of U.S. households with television sets. Neil Armstrong’s famous quote—That’s one small... -
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Altered RNA Splicing of Autism Risk Genes May Link to Behavioral Traits
Scientists at the Hospital for Sick Children (SickKids) and the University of Las Vegas Nevada (UNLV) have uncovered a genetic link between autism spectrum disorder (ASD) and a rare genetic condition called myotonic dystrophy type 1 (DM1). Headed by Ryan Yuen, PhD, senior scientist in the... -
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Viral Spread in the Gut Microbiome Mapped at Single-Particle Resolution
Scientists at the Charlie Dunlop School of Biological Sciences at UC Irvine report that they have developed a powerful new tool, called Phollow, that lets scientists watch viral activity in the gut microbiome of living animals with unprecedented precision—down to a single viral particle. Led by... -
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StockWatch: Investors Hungry for Lilly after Diabetes Pill Aces Phase III Trial
No sooner did Eli Lilly (NYSE: LLY)’s oral diabetes candidate orforglipron make history Thursday as the first oral small molecule glucagon-like peptide-1 (GLP-1) receptor agonist to ace a Phase III trial when investors roared their approval with a buying surge that sent the pharma giant’s stock... -
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Does Rainwater Make Plants Greener?
Many gardeners have noticed that grass is greener and plants look healthier after a good rain. They conclude that rainwater is better for gardens than tap water. Is that really true? Is rainwater better than tap water? Does rainwater make our gardens greener? Let’s open that umbrella and find...- Hoca
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Bypassing Size Constraints, Scientists Use CD36 Protein to Deliver Bulky PROTACs
Scientists from Duke University School of Medicine, the University of Texas (UT) Health Science, and the University of Arkansas have found a way to improve the uptake of proteolysis targeting chimeras (PROTACs) by cancer cells. Details are provided in a new Cell paper titled, “CD36-mediated... -
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New Strategy Enhances CRISPR Editing Efficiency for Therapeutic Use
While CRISPR-mediated gene editing has led to powerful advances across biology, medicine, and agriculture, challenges persist in optimizing the editing efficiency of enzymes, such as the widely used Cas9 nuclease. This is especially true in therapeutic use cases, where the goal is to attain high... -
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WuXi Biologics Reports Completion of First Commercial PPQ Campaign at 15,000 L Production Line
WuXi Biologics completed the first commercial project Process Performance Qualification (PPQ) campaign for its three sets of 5,000 L single-use bioreactors (SUBs) in the second drug substance line of its MFG20 facility at the Hangzhou site in China. The accomplishment not only marks a... -
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Long-Read Sequencing Pinpoints Genetic Basis for Psychiatric Diagnosis in Pediatric Case
Researchers at Rady Children’s Institute for Genomic Medicine (RCIGM) in San Diego have successfully applied long-read genome sequencing to reveal the genetic underpinnings of complex psychiatric conditions in a 17-year-old patient, showcasing the potential of this advanced technology for... -
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Brain Regions Essential for Logical Thinking and Problem Solving in Humans Identified
Using two newly developed types of reasoning tests, a team of researchers at UCL and UCLH has identified key brain regions that are essential for logical thinking and problem-solving. The results will help to increase our understanding of how the human brain supports reasoning skills that enable... -
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Multi-Zonal Liver Organoids Replicate Human Organs, Improve Injury Survival in Rodents
Scientists from Cincinnati Children’s Hospital Medical Center and their collaborators have used human stem cells to develop liver organoids that faithfully replicate key zones observed in human livers. Furthermore, when the organoids were transplanted into immunodeficient rats whose liver-bile... -
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After Job Cuts, “We’re Entering a Very New Territory for Biotech”
Lorenzo Paoletti Managing Director Biotech Investment Banking at Truist Securities The old saw, “You can’t tell the players without a scorecard,” is an especially fitting way of describing the effect of the overhaul in progress at the U.S. Department of Health and Human Services (HHS) and the... -
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Exploring the Mutational Landscape of Colorectal Cancer
Researchers from Japan report that they have characterized gene mutations in colorectal cancer (CRC) tumors with high tumor mutation burden that lack mutations in the major oncogenes. Their findings highlight alternate site-specific mechanisms of CRC development that can guide treatment... -
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Distinct Dendrites, Distinct Rules for Learning in a Single Neuron Mouse Study
How do we learn something new? How do tasks at a new job, lyrics to the latest hit song, or directions to a friend’s house become encoded in our brains? The broad answer is that our brains undergo adaptations to accommodate new information. To follow a new behavior or retain newly introduced...