- OxPhos System Evolution Explored, Indicating Links Between Mutations and Disease
- Unlocking the Mystery Behind Barrett’s Esophagus
- STING Inhibition Differences Revealed Between Humans and Mice
- Unnatural Products, Argenx Partner on Macrocyclic Peptides for Immune Disease
- LICORbio Acquires Serva Electrophoresis
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Novel Molecule May Rival GLP-1 Agonists for Diabetes and Obesity Treatment
The popularity of GLP-1-based drugs is testament to the importance of a drug that increases fat burning and lowers blood sugar. Now, a drug—taken in the form of a tablet—offers the outcome of GLP-1-based drugs (which are administered via injection) but with a different mechanism of action. The... -
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Rare Gene Mutation Delays Alzheimer’s by Damping Immune Cell Inflammatory Signaling
Researchers at Weill Cornell Medicine report that a rare gene mutation that delays Alzheimer’s disease does so by damping inflammatory signaling in brain-resident immune cells in a preclinical study. The finding adds to growing evidence that brain inflammation is a major driver of... -
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Brain Receptor Structure Revealed to Support Cerebellum Function Repair
The brain’s cerebellum plays a key role in coordinating movement, balance, and cognition. Injury to the cerebellum can have a profound impact on basic motor skills, such as sitting, standing, and walking. In a new study published in Nature titled, “Gating and noelin clustering of native... -
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Age-Related Macular Degeneration Slowed by Increasing Apolipoprotein M
An international research team headed by scientists at Washington University School of Medicine in St. Louis has identified a possible way to slow or block progression of age-related macular degeneration (AMD), a leading cause of blindness in people over age 50 years. Their study implicated... -
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Organ-Chip ALS Model Uses Patient iPSCs to Uncover Early Disease Progression
Amyotrophic lateral sclerosis (ALS) remains one of the most devastating and biologically elusive neurodegenerative diseases. Despite decades of research, its underlying mechanisms are still not fully understood. The condition presents a complex and highly variable interplay of genetic mutations... -
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StockWatch: CGT Stocks Fall on FDA Therapeutic Products Upheaval
The upheaval of personnel changes at the FDA flared anew this past week when Nicole Verdun, MD, super office director of the FDA’s Office of Therapeutic Products (OTP) at the Center for Biologics Evaluation and Research (CBER), and her deputy Rachael Anatol, PhD, were placed on administrative... -
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Intercellular Fluid Flow Impacts Tissue Response to Physical Forces
Water makes up around 60% of the human body. More than half of this water is inside the cells that make up organs and tissues, and much of the remaining water flows in the spaces between cells. MIT engineers have found that this intercellular fluid plays a major role in how tissues respond when... -
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US Pharmacopeia Recognizes Mass Photometry in New AAV Reference Standards for Gene Therapy Quality
The U.S. Pharmacopeia (USP) has recognized mass photometry as a key orthogonal method for characterizing its new adeno-associated virus (AAV) reference standards, as referenced in the draft general chapter <1067>, according to Refeyn. USP recently released new standards for measuring empty and... -
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King Faisal Specialist Hospital & Research Center and Germfree Labs Agree to Develop Advanced Therapy Manufacturing Campus in Riyadh
The King Faisal Specialist Hospital & Research Center (KFSHRC) and Germfree Laboratories agreed to partner to develop Saudi Arabia’s first fully integrated, modular advanced therapy Medicinal product (ATMP) manufacturing campus. The new facility will be located at KFSHRC’s main campus in Riyadh... -
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At BIO, Companies Launch New Products for AAV Manufacturing, AI Drug Discovery
At this year’s BIO International Convention, held June 16–19 in Boston, MA, two companies, 64x Bio and Fauna Bio, introduced new products aimed at improving therapy delivery and identifying novel drug targets for a range of human diseases, respectively. For its part, 64x Bio launched AAV... -
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Nanoparticle Drug Delivery System Improves Stability and Drug Loading
Scientists at Xi’an Jiaotong-Liverpool University (XJTLU) and at Nanjing University have combined a widely used medical polymer with a natural blood protein to develop a new nanoparticle drug delivery system that the team says can carry much larger amounts of disease-fighting drugs and remain... -
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QurAlis Opens New Global Headquarters
QurAlis opened its new global corporate headquarters in Cambridge, MA. The company’s new 30,000-sq-ft research facility and office space, located at 35 Cambridgepark, doubles QurAlis’ footprint in Alewife Biotech Park. “Maintaining our corporate headquarters in Cambridge positions us at the... -
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Bionova Scientific Expands Capacity and Joins Advanced Therapies Market
Bionova Scientific, a CDMO, is entering the advanced therapy manufacturing space by installing its third FlexFactory manufacturing platform while maintaining their core monoclonal antibody (mAb) business. Bionova will also use Cytiva’s Fast Trak process development services to help advance their... -
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Biofilm Formation by Microbial Pathogens Inhibited by Patterns on Medical Device Plastics
Scientists at the University of Nottingham have discovered how specific surface patterns on plastics used for medical devices can drastically reduce the ability of bacteria to attach and multiply, potentially offering an approach to help prevent infections on medical devices, such as catheters... -
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BIO 2025: Makary Calls for “New FDA” with Faster Reviews; Defends Agency’s Spring Job Cuts
BOSTON—FDA Commissioner Martin Makary, MD, shared his vision for a “New FDA”—one that would decide on drug applications much faster, partner with industry, and apply artificial intelligence (AI) and big data—with biopharma leaders attending the Biotechnology Innovation Organization (BIO)... -
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Integrative Exome Sequencing and Machine Learning Identify New Genes Contributing to Systemic Sclerosis Risk
Scientists at the Baylor College of Medicine and collaborating institutions used complementary approaches that integrate exome sequencing and evolutionary action machine learning to identify protein changes and their associated mechanisms in systemic sclerosis (SSc), a severe autoimmune disease... -
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Agenus and Noetik Collaboration Will Predict Cancer Biomarkers Using the Virtual Cell
Agenus, a clinical-stage immunotherapy company, and Noetik, an AI-focused multimodal biology start-up, have announced a research collaboration to develop predictive biomarkers for Agenus’s lead immuno-oncology combination, botensilimab (BOT) and balstilimab (BAL). The collaboration will apply... -
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Mabion Launches €500,000 Services Contest to Support Next-Gen Oncology Advances
Mabion, a CDMO based in Poland, launched a €500,000 ($574,000) oncology services contest at the BIO International Convention aimed at accelerating the development of recombinant protein-based cancer therapies. The contest will culminate at CPHI Worldwide in Frankfurt this October, spotlighting... -
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Systemic Sclerosis Organ Damage Revealed Through scRNA-Seq
Systemic sclerosis (SSc) is a rare autoimmune disease that can harden the skin, impair blood flow, and damage internal organs such as the lungs and kidneys. But no two patients experience the disease in the same way. Some remain stable for years, while others develop life-threatening... -
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Lilly to Acquire Verve Therapeutics for Up to $1.3B
Eli Lilly has agreed to acquire Verve Therapeutics for up to $1.3 billion, the companies said today, in a deal designed to bolster the buyer’s cardiovascular treatment pipeline with Verve’s gene edited therapies, led by PCSK9-targeting VERVE-102. The deal comes two months after publicly-traded...