- OxPhos System Evolution Explored, Indicating Links Between Mutations and Disease
- Unlocking the Mystery Behind Barrett’s Esophagus
- STING Inhibition Differences Revealed Between Humans and Mice
- Unnatural Products, Argenx Partner on Macrocyclic Peptides for Immune Disease
- LICORbio Acquires Serva Electrophoresis
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Xaira Therapeutics Releases Largest Perturb-Seq Dataset to Power the Virtual Cell
Ever since artificial intelligence (AI) drug developer Xaira Therapeutics launched in April 2024 with a jaw-dropping $1 billion in committed capital and a star-studded leadership lineup—including David Baker, PhD, the 2024 Nobel Laureate in Chemistry and University of Washington/HHMI... -
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New Enzyme Target Strategy Offers Hope for Neuroblastoma Therapy
Neuroblastoma, a pediatric cancer of the nervous system, remains the leading cause of cancer-related death in young children, particularly when the disease has spread. Despite aggressive treatment regimens that include surgery, radiation, chemotherapy, and immunotherapy, metastatic neuroblastoma... -
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AI-Designed Proteins Created De Novo with New AlphaDesign
The proteins found in nature represent only a tiny fraction of the nearly limitless protein structures that could theoretically exist. By designing proteins de novo—from scratch—scientists can more efficiently create novel therapeutics tailored for specific biological functions. In a new study... -
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cfDNA Detects Complications in Patients After Liver Transplant
Liver transplant is a lifesaving surgery, but a significant number of patients experience organ rejection or other complications. A study by scientists at Georgetown University and MedStar Health has shown that a single blood sample can be used to detect problems at the earliest stages, allowing... -
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Simtra BioPharma Solutions and MilliporeSigma Partner on Antibody Drug Conjugate Drug Substance and Product Manufacturing
Simtra BioPharma Solutions, a CDMO, formed a five-year strategic alliance with the life science business of Germany-based Merck KGaA, which operates as MilliporeSigma in the U.S. and Canada. The partnership was designed to create a turnkey offering for biopharmaceutical companies seeking... -
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Proteogenomics Algorithm Improves the Detection of Hidden Genetic Mutations
Proteogenomics explores how genetic information translates into protein expression and function, and the role of changes across DNA, RNA, and proteins in influencing disease development and progression. A major challenge is the inability to accurately detect variant peptides, as existing... -
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Chrysalis Launches with Acquired Cleanroom Assets to Deliver Flexible Manufacturing Solutions
Chrysalis, which bills itself as a GMP-ready space and service provider for CDMOs, has officially launched following the acquisition of facility assets from Azzur Group and an ownership investment to fuel future growth and expansion. With facilities in Massachusetts and North Carolina... -
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Nanoneedle Patch Could Offer Alternative to Painful Tissue Biopsies
Scientists at King’s College London have developed a patch comprising tens of millions of microscopic nanoneedles, which they suggest could offer a painless and less invasive alternative to biopsies for millions of patients worldwide who undergo these procedures each year to detect and monitor... -
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This Week in Gaming News: June 9th – June 15th, 2025
Summer gaming season is officially over (at least until Gamescom lands in August), so we can all breathe a little bit easier, safe in the knowledge we’re not going to miss any seismically important announcements. Of course, that doesn’t mean there hasn’t been any news at all; as usual, the world... -
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Celiac Disease Detection Made Easier With T Cell Reactivity Test
Finding out if you have celiac disease is not easy. Diagnosing the autoimmune disease in the United States requires two tests. First, a blood test to identify elevated levels of certain antibodies, most commonly tTG-IgA (tissue transglutaminase IgA). In the event of a positive blood test, an... -
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Second DMD Patient Dies After Treatment with Sarepta Gene Therapy
Sarepta Therapeutics said it has temporarily suspended shipments of Elevidys® (delandistrogene moxeparvovec-rokl) for infusion in non-ambulatory patients following the second death in three months of a patient with Duchenne muscular dystrophy (DMD) following treatment with the marketed gene... -
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Viral Ribosome Profiling Could Speed Vaccine Development
Vaccinations have revolutionized healthcare, but designing them remains complex, requiring time and creativity, especially for vaccines against viruses, which are difficult to study. “Each virus demands a specific culturing system, some viruses cannot be cultured in the lab, and highly... -
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Movement Mobilizes Microglia, Astrocytes to Protect Against Alzheimer’s in snRNA-seq Mice Study
Using single-nuclei RNA sequencing (snRNA-seq), scientists from Mass General Brigham, SUNY Upstate Medical University, and elsewhere have identified specific brain cell types in the hippocampus that respond best to physical exercise in mouse models of Alzheimer’s disease. The findings help to... -
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Rapid Formation of Vascular Organoids from iPSCs via TF Activation
Blood vessels are vital to nearly every tissue in the body, delivering oxygen and nutrients, maintaining hemostasis, and modulating inflammation. Recreating these functional vascular networks in vitro is foundational for both basic research and translational applications. Yet most methods for... -
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Brain Implants Monitor Neural Activity in Tadpoles Throughout Embryonic Development
Bioengineering researchers at the Harvard John A. Paulson School of Engineering and Applied Sciences (SEAS) have developed a soft, thin, stretchable bioelectronic device that can be implanted into a tadpole embryo’s neural plate—the early-stage, flat structure that folds to become the 3D brain... -
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Early Steps in Amyloid-Beta Plaque Formation Tracked in Alzheimer’s Disease
After studying 140,000 versions of the Aβ42 peptide, scientists identified some of the earliest molecular interactions that drive the formation of harmful amyloid protein aggregates found in Alzheimer’s disease cases. Their findings are published in a Science Advances paper titled, “Massively... -
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MaxCyte and Ori Biotech Collaborate on Manufacturing Autologous Cellular Therapies
MaxCyte and Ori Biotech entered into a strategic collaboration aimed at enhancing efficiency, scalability, and productivity in cell therapy manufacturing. The collaboration combines the MaxCyte ExPERT platform and Flow Electroporation® technology with Ori’s next-generation cell therapy... -
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Infinimmune’s AI Model GLIMPSE-1 Engineers Human-Sourced Antibodies
In April, the FDA announced an ambitious plan to phase out animal testing requirements for monoclonal antibodies and other therapies in an effort to improve drug safety and reduce R&D costs. The goal is to pursue potentially more effective human-relevant methods for drug development, including... -
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Knot a Problem: Mechanism Found for DNA Loop Control
Not all DNA looks like the familiar double helix. Sometimes, parts of our genetic code fold into unusual shapes under certain conditions. One such structure known as a G-quadruplex (G4) looks like a knot. These knot-like conformations can play important roles in turning genes on or off. But if... -
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Nicoya Grows Biologics Characterization Capabilities with Applied Photophysics Acquisition
Nicoya Lifesciences has acquired Applied Photophysics, a British-based provider of biophysical characterization instruments, for an undisclosed price, in a deal designed to bolster Nicoya’s biologics characterization capabilities and accelerate its global expansion. By combining with Applied...