- OxPhos System Evolution Explored, Indicating Links Between Mutations and Disease
- Unlocking the Mystery Behind Barrett’s Esophagus
- STING Inhibition Differences Revealed Between Humans and Mice
- Unnatural Products, Argenx Partner on Macrocyclic Peptides for Immune Disease
- LICORbio Acquires Serva Electrophoresis
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This Week in Gaming News: May 26th – June 1st, 2025
For some, this week marks the official beginning of summer; if you subscribe to the meteorological definition of the seasons, then June 1st is the start of what many consider to be their favourite season. We know, we know, we’re partial to starting off with a discussion of the weather, but what... -
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Plasma Exchange in Humans Reduces Biological Age by over Two Years
In a first, a randomized, placebo-controlled trial has been performed to assess the safety and effects on biological age of therapeutic plasma exchange (TPE) regimens in healthy adults over 50. Therapeutic plasma exchange is a procedure that separates, removes, and replaces patient plasma to... -
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BioAgilytix Expands Global CMC Analytical Services
BioAgilytix reports that it has expanded its global chemistry, manufacturing, and controls (CMC) analytical testing capabilities with the recently completed buildout of a 76,000-ft2 campus in Durham, NC, including 26,000-ft2 dedicated to a GMP compliant laboratory. This expansion represents a... -
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New Spatial Technology Unveils Nanoscale Genome Structure Associated with Aging
Tapping into the structural intricacies of the cell nucleus was once a pipe dream, Jason Buenrostro, PhD, told me when reflecting on the early beginnings of the spatial genomics field. When he started his lab as an institute member at the Broad Institute eight years ago, sifting through millions... -
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Neurodegeneration Slowed by Sleep Aid That Reduces Tau Buildup in Mice
Data from a new study in mice shows that a common sleep aid protects the brain from damage seen in neurodegenerative disorders, in addition to improving rest. Specifically, scientists from Washington University School of Medicine in St. Louis (WashU Medicine) and their collaborators elsewhere... -
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Old Vaccine, New Tricks: PIE-seq Reveals How BCG Reprograms Immunity
How can a tuberculosis vaccine also treat cancer—and potentially make other immunotherapies more effective? That’s the question researchers at Memorial Sloan Kettering Cancer Center (MSK) and Weill Cornell Medicine are helping answer with new insights into Bacillus Calmette-Guérin (BCG), a live... -
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StockWatch: Intellia Stumbles on News of Patient’s Severe Liver Toxicity
Intellia Therapeutics (NASDAQ: NTLA) found out this past week what other genetic medicine developers have learned in recent weeks: Any safety issue that arises in a clinical trial is enough to send investors scrambling to sell their shares. Intellia saw its stock tumble 23% Thursday to $7.45... -
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“Universal” CAR-T Immunotherapy Targets Relapsed/Refractory Blood Cancers
A new type of allogeneic CAR-T cell immunotherapy that targets aggressive blood cancers has shown promising results alongside manageable side effects, according to the results of an international Phase 1/2 clinical trial led by researchers at Washington University School of Medicine in St... -
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Nuclera and Cytiva Collaborate on Protein Characterization for Drug Development
Nuclera agreed to collaborate with Cytiva to focus on accelerating the production, purification, and characterization of proteins needed for pharma R&D. The collaboration will work with Nuclera’s eProteinTM Discovery System with Cytiva’s Biacore surface plasmon resonance (SPR) technology... -
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PEG Alternative Minimizes Immunogenicity from LNP-Based Therapies
A new material developed at Cornell University could significantly improve the delivery and effectiveness of mRNA vaccines by replacing a commonly used ingredient in lipid nanoparticles (LNPs) that may trigger unwanted immune responses in some people. Traditional lipid nanoparticle formulations... -
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Snowball Toss: Arctic Aim – Fun Winter Target Game Online
Snowball Toss: Arctic Aim – Fun Winter Target Game Online About The Game Welcome to a frosty, fun-filled winter wonderland where your snowball-throwing skills are put to the test! In “Winter Snowball Game”, you’re tasked with hitting moving targets with snowballs while navigating an increasingly... -
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More Mutations in Childhood Cancer Might Mean More Therapy Options
Childhood cancers are often considered genetically simple, containing few mutations. However, this notion has been challenged in a new study that found an unexpectedly high number of mutations in a pediatric kidney cancer. The findings open the door to rethinking treatment strategies... -
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Base Editors Curb Repeating DNA in Huntington’s and Ataxia Models
Armed with base editors, scientists from the laboratory of David Liu, PhD, professor and director of the Merkin Institute of Transformative Technologies in Healthcare at the Broad Institute, and their collaborators elsewhere, successfully made changes to the defective gene responsible for... -
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Absci Advances Lead AI-Designed Candidate for IBD into the Clinic
Absci, which engineers biologic drugs based on its own generative AI platform, has advanced its lead candidate into the clinic by dosing the first healthy volunteers. The trial is designed to assess the antibody’s ability to treat inflammatory bowel disease (IBD) by targeting tumor necrosis... -
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Alcohol Abuse Drug May Help Reduce Cell Death Induced by Trauma
A drug called disulfiram (DSF), which is used to prevent alcohol abuse, may also help to interrupt the runaway cell death and inflammation that is triggered by severe trauma, according to the results of research by University of Pittsburgh School of Medicine surgeon-scientists. The team’s newly... -
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Benefits of Breaking Up Virus-Like Particles for Biomanufacturing
Breaking virus-like particles (VLPs) into smaller subunits and then reassembling them afterwards can solve many of the traditional problems with manufacturing them. That’s the message of a talk by an Australian scientist earlier this year. Lukas Gerstweiler, PhD, a lecturer at the University of... -
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The Best Games for June 2025
One very big gaming release looms over the month of June this year. That’s right: we are, of course, talking about the Gex Trilogy re-release, which lands in the middle of the month. Apparently, Nintendo is also planning to release a new console in June, and there are some who are claiming this... -
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Danon Disease Patient Dies in Rocket Gene Therapy Trial
Rocket Pharmaceuticals acknowledged the death of a patient in a pivotal trial assessing its Danon disease gene therapy candidate RP-A501, a study that the FDA has placed on clinical hold. The patient, whose age was not disclosed, suffered an unexpected serious adverse event (SAE) that involved... -
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T Cell Memory May Explain Chikungunya-Linked Chronic Pain
For most people infected with Chikungunya virus (CHIKV), the illness is over in a few weeks, marked by a febrile illness, rash, and joint and muscle pain. But for as many as 60% of patients, the virus leaves behind a far more persistent symptom: incapacitating joint pain, called arthralgia, that... -
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Genetic Links for Common Inflammatory Arthritis Open Treatment Options
Calcium pyrophosphate deposition disease (CPPD), or pseudogout, is one of the most common forms of inflammatory arthritis in individuals over 60 years of age and is characterized by the deposition of CPP crystals in articular tissues, leading to recurrent painful attacks and chronic joint...