- OxPhos System Evolution Explored, Indicating Links Between Mutations and Disease
- Unlocking the Mystery Behind Barrett’s Esophagus
- STING Inhibition Differences Revealed Between Humans and Mice
- Unnatural Products, Argenx Partner on Macrocyclic Peptides for Immune Disease
- LICORbio Acquires Serva Electrophoresis
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Synthetic Biosensor Monitors Drugs In Vivo Over Time
The ability to continuously monitor the molecular state of our body could be harnessed to help optimize drug delivery or enable early detection of deadly diseases like cancer. For the last two decades, research has aimed to achieve this by developing biosensors that measure chemical or... -
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Wacker and Expression Manufacturing Partner to Advance Lentiviral-Based Gene and Cell Therapies
Wacker Biotech US, a CDMO, and Expression Manufacturing, which specializes in viral vector technology, agreed to collaborate to advance the development and manufacturing of lentiviral-based gene and cell therapies. The goal is to offer biopharma and biotech clients with an end-to-end, optimized... -
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This Week in Gaming News: May 19th – May 25th, 2025
Summer is just around the corner, and what better way to celebrate its arrival than to spend some time looking at what’s been happening in the world of gaming this week? Alright, alright, so that’s what we were planning to do anyway, but hey, any excuse is as good as any other, right? If you’ve... -
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Do Lettuce Seeds Need Light to Germinate?
A lot of specialty seeds need light to germinate, but it never occurred to me that vegetable seeds might need light until a couple of months ago, when I read that lettuce needs light. I have always covered my lettuce seed, and it germinated just fine. How can that be if they need light? How ...- Hoca
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Several ALS Patients See Remarkable Response to ASO Treatment
Typically, the goal of ALS treatments is to slow the disease or halt progression. But new data from the antisense oligonucleotide (ASO) jacifusen for FUS-ALS show that two patients went beyond the expected, and showed improvements. “When testing new drugs for ALS, we do not expect to see... -
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Motor Protein Dynamics Guide Brain Disease Drug Targeting
The cell cytoskeleton is modulated by motor proteins, known as dyneins, that generate force and movement on microtubules to control a wealth of biological processes, including motility, cell division, and intracellular transport. Mutation of Lis1, a key dynein regulator, can lead to the rare... -
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AI-Designed Protein Moves Mimics Natural Movement
Scientists from the University of California, San Francisco (UCSF), have used deep learning techniques to design an approach for generating artificial proteins that can move and change shape much like natural proteins. Full details of the work are provided in a new Science paper titled “Deep... -
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Fertilizer in Potting Soil – Good or Bad?
In the good old days, commercial potting soil (media) contained no added fertilizer. Today, more and more products contain some fertilizer, either in synthetic or organic form. Gardeners have been led to believe they can fertilize less and skip fertilizing seedlings. Some believe they can stop...- Hoca
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- Forum: Software development
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A Suite of Enhancer AAVs Support Targeted Gene Therapy for Brain Disease
The mammalian cortex, the region of the brain responsible for a wide range of higher-level cognitive functions, including sensory perception, motor control, and complex thought, is composed of a diverse array of cell types. Defining the contribution of each cell type to cortex function is an... -
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Cryo-MS Reveals Lipid Nanoparticles’ Surface Secrets
Using cryogenic mass spectrometry, scientists from the University of Nottingham’s School of Pharmacy and their collaborators elsewhere developed an approach for depth profiling frozen lipid nanoparticles (LNPs) to reveal the layers and orientation of the constituent molecules. Their research... -
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Blood Aging Revealed Through a Novel Epigenetic Clonal Tracing Method
The blood system changes over time: a subset of stem cells outcompete their neighbors and gradually take over blood production. In addition, the blood stem cell reservoir shrinks and becomes dominated by clones that show a preference for producing myeloid cells, immune cells linked to chronic... -
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SSRI Antidepressants May Also Be Anticancer
A widely used antidepressant drug could help the immune system fight cancer, according to UCLA research. The newly reported study showed that selective serotonin reuptake inhibitors (SSRIs) significantly enhanced the ability of T cells to fight cancer and suppressed tumor growth across a range... -
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Waters Acquires Halo Labs
Waters acquired Halo Labs, which specializes on imaging technologies to detect, identify, and count interfering materials (particles) in therapeutic products, such as cell, protein, and gene therapies. The Aura platform from Halo Labs features a methodology that performs full spectrum particle... -
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Zevra Cashes in on First FDA-Approved NPC Treatment with PRV
Neil F. McFarlane, Zevra Therapeutics President and CEO After gaining FDA approval for Miplyffa® (arimoclomol) as the first-ever therapy indicated to treat Niemann-Pick disease type C (NPC), Zevra Therapeutics has cashed in on the regulatory win by closing on the sale of a Rare Pediatric... -
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First Vascularized Organoid Model of Stem Cell-Derived Pancreatic Islets
An international team of researchers led by Max Delbrück Center Scientific Director Professor Maike Sander, MD, has for the first time developed an organoid model of human pluripotent stem cell-derived pancreatic islets (SC-islets) with integrated vasculature. Researchers in the Sander lab at... -
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Block Drop Game – The Modern Tetris Alternative You Need to Try
Block Drop Game – The Modern Tetris Alternative You Need to Try What is Block Drop? Block Drop is one of the most iconic puzzle-style games inspired by classics like Tetris. In this version, you manipulate falling geometric shapes (called “tetrominoes”) to create complete horizontal lines that... -
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Fertilizer PPM Calculator
Gardeners normally talk about “teaspoons” of fertilizer when they make up fertilizer solutions, which leads to all kinds of confusion and misuse of fertilizer. Some of you are using too little, while others use way too much. On the other hand, horticultural professionals don’t make these...- Hoca
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- Forum: Software development
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Oligo Factory’s Low-Scale Synthesis Expands Access to Small, GMP-Ready Custom Nucleotides
Throughout his career, Luke Dannenberg, PhD, has held multiple positions in industry and academia that have put him in close proximity to oligonucleotide technologies. Trained as a scientist, he transitioned into industry roles in 2006 working first at a microarray company that used oligos... -
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Potential ALS Mitochondrial Target Identified with CRISPR, scRNA-seq
Eleven years after the Ice Bucket Challenge brought ALS into the public spotlight, the neurodegenerative disease is once again drawing scientific attention—this time through the lens of CRISPR and single-cell genomics. A new study published in Nature Communications, “Single-cell RNA-sequencing... -
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Northway Biotech Signs Deal with Kaida BioPharma for Production of Kaida’s Ovarian Cancer Therapeutic
Officials at Northway Biotech say they will leverage the company’s expertise to develop a robust manufacturing process for KAD101. This involves Northway’s developing and qualifying analytical methods, optimizing the formulation, development and scaling up of the production process, and...