- OxPhos System Evolution Explored, Indicating Links Between Mutations and Disease
- Unlocking the Mystery Behind Barrett’s Esophagus
- STING Inhibition Differences Revealed Between Humans and Mice
- Unnatural Products, Argenx Partner on Macrocyclic Peptides for Immune Disease
- LICORbio Acquires Serva Electrophoresis
Search results
-
H
OxPhos System Evolution Explored, Indicating Links Between Mutations and Disease
Mitochondria are known as the body’s “energy factories,” and their function is essential for life. Inside mitochondria, a set of complexes called the oxidative phosphorylation (OxPhos) system represents the main site of metabolic and energy integration in the cell and acts like a biochemical... -
H
Unlocking the Mystery Behind Barrett’s Esophagus
A team led by researchers at Baylor College of Medicine and Washington University School of Medicine has shed light on the process that drives Barrett’s esophagus formation. This condition affects the lining of the esophagus and increases the risk of developing esophageal adenocarcinoma, a... -
H
STING Inhibition Differences Revealed Between Humans and Mice
Researchers have long focused on the Stimulator of Interferon Genes (STING) pathway, a key component of the innate immune system, as an approach to recruit immune cells to target cancer. However, stimulation of the pathway can also exacerbate many inflammatory diseases, emphasizing a need for... -
H
Unnatural Products, Argenx Partner on Macrocyclic Peptides for Immune Disease
When asked why he founded Unnatural Products (UNP), a developer of oral macrocyclic peptide therapeutics, Cameron Pye, PhD, attributes the decision at least in part to “being in the right place at the right time.” Pye and his co-founder Joshua Schwochert, PhD, met as doctoral students in the... -
H
LICORbio Acquires Serva Electrophoresis
LICORbio acquired Serva Electrophoresis, a privately held company founded in 1953 and which provides electrophoresis reagents, consumables, and workflow instrumentation. The transaction strengthens LICORbio’s position as a solutions provider in protein analysis, said Tom Reslewic, CEO of... -
H
ProBio Opens Flagship U.S. Plasmid & Viral Vector Manufacturing Facility
ProBio, a CDMO and subsidiary of GenScript Biotech, opened its flagship Cell and Gene Therapy Center of Excellence at the Princeton West Innovation Campus in Hopewell, NJ. The 128,000-sq-ft GMP facility is purpose-built for manufacturing plasmid DNA and viral vectors, including adeno-associated... -
H
Secrets of Rapid Scarless Mouth Healing Uncovered via scRNA-Seq
A preclinical study in mice and human tissue has uncovered a molecular pathway that may help to explain why wounds inside the mouth can heal quickly and without scars. The researchers, co-led by teams at Cedars-Sinai, Stanford Medicine and the University of California, San Francisco (UCSF), used... -
H
Healx and SCI Ventures Partner to Uncover Cures for Paralysis with AI-Driven Drug Discovery
Healx, an expert in AI-powered drug discovery for rare and neglected conditions, has partnered with SCI Ventures to try to accelerate the discovery and development of therapies for spinal cord injury (SCI) using artificial intelligence. This collaboration will apply Healx’s AI platform to... -
H
Myosin-Targeting Drug Sensitizes Glioblastoma to Treatment in Mice
Each year, about 14,000 people in the United States are diagnosed with glioblastoma, one of the deadliest primary brain tumors. With standard treatments of surgery, radiation, and chemotherapy offering a median survival of 14–16 months—and approximately half of patients harboring tumors... -
H
Enzyme Inhibition Restores Neuron Pathways in a Parkinson’s Mouse Model
In a new study published in Science Signaling titled, “Restoration of striatal neuroprotective pathways by kinase inhibitor treatment of Parkinson’s linked-LRRK2 mutant mice,” researchers from Stanford University and University of Dundee have shown that inhibition of a specific enzyme may rescue... -
H
Electrical Stimulation of Prefrontal Cortex Boosts Math Performance
An international team of scientists led by the University of Surrey has discovered that a form of safe, painless, and non-invasive brain stimulation could help people who are at risk of falling behind in math. The study by Roi Cohen Kadosh, PhD, and colleagues showed that the strength of certain... -
H
Enhancing ASOs Efficacy by Slowing Down Intracellular Transport
Anti-sense oligonucleotides (ASOs) are short, modified, single-stranded oligonucleotides—made from DNA or locked nucleic acid (LNA)—with enhanced stability, activity, and bioavailability. They associate with RNA through sequence complementarity and can modify the expression (and/or splicing... -
H
Genetic Effects of Chemotherapy Revealed to Guide Cancer Treatment
In a new study published in Nature Genetics titled, “The long-term effects of chemotherapy on normal blood cells,” researchers from the Wellcome Sanger Institute, the University of Cambridge, and Cambridge University Hospitals NHS Foundation Trust (CUH) have uncovered new patterns of DNA damage... -
H
PFAS “Forever Chemicals” Absorbed via Human Gut Bacteria in Mice
Per- and polyfluoroalkyl substances (PFAS)—the so-called “forever chemicals”—have long been known to accumulate in the human body, raising alarms due to links with decreased fertility, cardiovascular disease, and cancer. In a mouse study published in Nature Microbiology, titled “Human gut... -
H
Dengue Severity Linked to Genetic Ancestry’s Influence on Immune Response
Researchers at the University of Pittsburgh, University of Pittsburgh Medical Center, and Instituto Aggeu Magalhães, have for the first time linked the extreme variability in severity of the mosquito-borne viral disease, dengue, between individuals, to the influence of genetic ancestry on... -
H
University of Oklahoma Celebrates Grand Opening of its 4,000-sq-ft Bioprocessing Core Facility
The University of Oklahoma (OU) celebrated the grand opening of its 4,000-sq-ft bioprocessing core facility (BCF) with a ribbon-cutting ceremony. This multimillion-dollar facility is a key piece in the state’s drive to become a national leader in biomanufacturing and biotech workforce... -
H
EPA Signatories Share Five Critical Areas of Concern
Nearly 500 civil servants working at the EPA and over 2000 supporters (at the time of publication) have signed an open letter to Administrator Lee Zeldin in a Declaration of Dissent. This letter comes less than a month after a similar statement from NIH scientists was sent to Director Jay... -
H
The Best Games for July 2025
After the launch of the Nintendo Switch 2, you’d be forgiven for thinking that July looks like a quieter month for game releases. It turns out that the opposite is actually true; there’s so much good stuff coming out in July that we’re not even sure we’re going to get much of a chance to [...]... -
H
Sugar Metabolism Opens Avenue for Protection Against Neurodegeneration
In a new study published in Nature Metabolism titled “Neuronal Glycogen Breakdown Mitigates Tauopathy via Pentose Phosphate Pathway-Mediated Oxidative Stress Reduction,” researchers from the Buck Institute for Research on Aging have uncovered how the breakdown of glycogen may protect the brain... -
H
Microbiota Vault Initiative Update Given on World Microbiome Day
Last Friday, June 27, was World Microbiome Day. The theme was “Microbiome 101: What You Need to Know” with the overall goal of “simplifying the science, focusing on raising awareness, and providing clear, accessible information about microbiomes.” An announcement was coordinated with the day...